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How Early Can Alzheimer’s Occur

Suggestions For Eating Healthy Food:

Neuroimaging and Biomarkers: How Early Can We Diagnose Alzheimer’s?
  • Eat more fruits and vegetables
  • Focus on lean protein, like fish
  • Choose foods with “healthy fats,” such as olive oil, flaxseed, avocado, and nuts

If youve been recently diagnosed with Alzheimers or another dementia, then its possible that food may not taste as good due to the loss of the sense of taste and smell. However, its still important to keep eating a healthy diet for overall health benefits.

How Is Alzheimers Diagnosed And Treated

Doctors may ask questions about health, conduct cognitive tests, and carry out standard medical tests to determine whether to diagnose a person with Alzheimers disease. If a doctor thinks a person may have Alzheimers, they may refer the person to a specialist, such as a neurologist, for further assessment. Specialists may conduct additional tests, such as brain scans or lab tests of spinal fluid, to help make a diagnosis. These tests measure signs of the disease, such as changes in brain size or levels of certain proteins.

There is currently no cure for Alzheimers, though there are several medicines approved by the U.S. Food and Drug Administration that can help manage some symptoms of the disease along with coping strategies to manage behavioral symptoms. In 2021, FDA provided accelerated approval for a new medication, aducanumab, that targets the protein beta-amyloid, which accumulates abnormally in the brains of people with Alzheimers. The new medication helps to reduce amyloid deposits, but has not yet been shown to affect clinical symptoms or outcomes, such as progression of cognitive decline or dementia.

Most medicines work best for people in the early or middle stages of Alzheimers. Researchers are exploring other drug therapies and nondrug interventions to delay or prevent the disease as well as treat its symptoms.

Key Points About Early

  • Alzheimer disease commonly affects older people, but early-onset Alzheimer disease can affect people in their 30s or 40s.

  • It affects memory, thinking, and behavior.

  • Although there is no known cure, early diagnosis and treatment can lead to better quality of life.

  • Stay healthy with a good diet and regular exercise.

  • Avoid alcohol and other substances that may affect memory, thinking, and behavior.

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Signs And Symptoms Of Alzheimer’s Disease

Memory problems are typically one of the first signs of cognitive impairment related to Alzheimers. Some people with memory problems have a condition called mild cognitive impairment . With MCI, people have more memory problems than normal for their age, but their symptoms do not interfere with their everyday lives. Movement difficulties and problems with the sense of smell have also been linked to MCI. Older people with MCI are at greater risk for developing Alzheimers, but not all of them do so. Some may even revert to normal cognition.

The first symptoms of Alzheimers vary from person to person. For many, decline in nonmemory aspects of cognition, such as word-finding, vision/spatial issues, and impaired reasoning or judgment may signal the very early stages of the disease. Researchers are studying biomarkers to detect early changes in the brains of people with MCI and in cognitively normal people who may be at greater risk for Alzheimers. More research is needed before these techniques can be used broadly and routinely to diagnose Alzheimers in a health care providers office.

Problems With Vision And Spatial Awareness

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Alzheimers disease can sometimes cause , making it difficult for people to judge distances between objects. The person may find it hard to distinguish contrast and colors or judge speed or distance.

These vision problems combined can affect the persons ability to drive.

Typical aging also affects eyesight, so it is essential to have regular checkups with an eye doctor.

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Who Has Alzheimers Disease

  • In 2020, as many as 5.8 million Americans were living with Alzheimers disease.1
  • Younger people may get Alzheimers disease, but it is less common.
  • The number of people living with the disease doubles every 5 years beyond age 65.
  • This number is projected to nearly triple to 14 million people by 2060.1
  • Symptoms of the disease can first appear after age 60, and the risk increases with age.

Conditions With Symptoms Similar To Dementia

Remember that many conditions have symptoms similar to dementia, so it is important not to assume that someone has dementia just because some of the above symptoms are present. Strokes, depression, excessive long-term alcohol consumption, infections, hormonal disorders, nutritional deficiencies and brain tumours can all cause dementia-like symptoms. Many of these conditions can be treated.

Read Also: How Are Dementia And Alzheimer’s Disease Related

What Is Known About Alzheimers Disease

Scientists do not yet fully understand what causes Alzheimers disease. There likely is not a single cause but rather several factors that can affect each person differently.

  • Age is the best known risk factor for Alzheimers disease.
  • Family historyresearchers believe that genetics may play a role in developing Alzheimers disease. However, genes do not equal destiny. A healthy lifestyle may help reduce your risk of developing Alzheimers disease. Two large, long term studies indicate that adequate physical activity, a nutritious diet, limited alcohol consumption, and not smoking may help people. To learn more about the study, you can listen to a short podcast.
  • Changes in the brain can begin years before the first symptoms appear.
  • Researchers are studying whether education, diet, and environment play a role in developing Alzheimers disease.
  • There is growing scientific evidence that healthy behaviors, which have been shown to prevent cancer, diabetes, and heart disease, may also reduce risk for subjective cognitive decline. Heres 8 ways.

Support For Family And Friends

Living with early onset Alzheimer’s disease

Currently, many people living with Alzheimers disease are cared for at home by family members. Caregiving can have positive aspects for the caregiver as well as the person being cared for. It may bring personal fulfillment to the caregiver, such as satisfaction from helping a family member or friend, and lead to the development of new skills and improved family relationships.

Although most people willingly provide care to their loved ones and friends, caring for a person with Alzheimers disease at home can be a difficult task and may become overwhelming at times. Each day brings new challenges as the caregiver copes with changing levels of ability and new patterns of behavior. As the disease gets worse, people living with Alzheimers disease often need more intensive care.

You can find more information about caring for yourself and access a helpful care planning form.

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Mood Or Personality Changes

Someone with Alzheimers disease may start to experience a change in mood . They can feel irritable, confused, anxious, or depressed. They may also lose interest in things they used to enjoy.

They could become frustrated with their symptoms or feel unable to understand the changes taking place. This may present as aggression or irritability toward others.

What Are The Signs Of Alzheimer’s Disease

Scientists continue to unravel the complex brain changes involved in the onset and progression of Alzheimers disease. It seems likely that damage to the brain starts a decade or more before memory and other cognitive problems appear. During this preclinical stage of Alzheimers disease, people seem to be symptom-free, but toxic changes are taking place in the brain.

Damage occurring in the brain of someone with Alzheimers disease begins to show itself in very early clinical signs and symptoms. For most people with Alzheimersthose who have the late-onset varietysymptoms first appear in their mid-60s. Signs of early-onset Alzheimers begin between a persons 30s and mid-60s.

The first symptoms of Alzheimers vary from person to person. Memory problems are typically one of the first signs of cognitive impairment related to Alzheimers disease. Decline in non-memory aspects of cognition, such as word-finding, vision/spatial issues, and impaired reasoning or judgment, may also signal the very early stages of Alzheimers disease. And some people may be diagnosed with mild cognitive impairment. As the disease progresses, people experience greater memory loss and other cognitive difficulties.

Alzheimers disease progresses in several stages: preclinical, mild , moderate, and severe .

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Confusion About Location And Time

The person may experience confusion about places or times. They could have difficulty keeping track of seasons, months, or times of day.

They may become confused in an unfamiliar place. As Alzheimers disease progresses, they could feel confused in familiar places or question how they got there. They may also start to wander and get lost.

What Is Early Onset Familial Alzheimer Disease

Alzheimers Disease: Stages, Sign and diagnosis Coding  Passionate In ...

Definition: What Is eFAD?

Early onset familial Alzheimer disease is hereditary and marked by Alzheimer disease symptoms that appear at an unusually early age. Symptoms can start in a person’s thirties, forties, and fifties . Generally, if you are diagnosed with eFAD, then one of your parents will also have had it if he or she lived long enough, and your siblings and your children may have a 50-50 chance of having inherited it. Very rarely, eFAD can make a first-time appearance in a family through a new genetic mutation.

Genetics researchers studied eFAD families to discover the three known genes that cause familial AD: amyloid precursor protein , presenilin-1 , and presenilin-2 . Of these, PS1 mutations account for most eFAD, while APP and PS2 are more rare. Having a pathogenic mutation in one of these three genes virtually guarantees that one will develop early onset Alzheimer disease. Tests can determine which gene is at fauly . There are also cases of eFAD that cannot be linked to one of these three genes. There may be additional genes waiting to be discovered, if only researchers could connect with more eFAD families.

Prognosis: Is eFAD Different from LOAD?

How Common Is Early Onset Familial Alzheimer Disease?

For practical and research purposes, doctors and scientists need defined populations for study and the numbers change based on the definitions. The definition would seem to rest on two criteria:

Early onset sporadic Late-onset sporadic

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Difficulty Determining Time Or Place

Losing track of dates and misunderstanding the passage of time as it occurs are also two common symptoms. Planning for future events can become difficult because they arent immediately occurring.

As symptoms progress, people with AD can become increasingly forgetful about where they are, how they got there, or why theyre there.

How Do I Treat Early

An important part of managing your condition is to stay as positive as you can. Keep up with the activities you still enjoy. Try different ways to relax, like yoga or deep breathing.

Keep your body in good shape, too. Make sure you eat healthy food and get regular exercise.

Medications can help with some symptoms of early-onset Alzheimer’s. Your doctor may prescribe drugs to help with memory loss, such as:

These medicines can delay or improve your symptoms for a few months to a few years. They may give you more time to live independently.

The doctor also may also suggest sleeping pills, antidepressants, or tranquilizers to manage other problems related to Alzheimer’s, like insomnia, night terrors, and anxiety.

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Tips For Doctors Appointments

Before you visit a doctor, there are a few things to keep in mind or prepare for in advance:

  • Know that not all symptoms may be due to Alzheimers disease or dementia
  • Understand that it may take more than one doctor, multiple appointments, and several tests to find out if you or your loved one might have Alzheimers disease or another cause of dementia
  • Be honest about your or your loved ones symptoms and concerns
  • Gather information on your or your loved ones family health history, medical history, and lifestyle
  • Bring a list of current medications, vitamins, or supplements that you or your loved one is taking
  • Have someone you trust come with you to your appointment for support and to help take notes

Symptoms Of Mild Cognitive Impairment

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Some people have a condition called mild cognitive impairment, or MCI. It can be an early sign of Alzheimers. But, not everyone with MCI will develop Alzheimers disease. People with MCI can still take care of themselves and do their normal activities. MCI memory problems may include:

  • Losing things often
  • Forgetting to go to events or appointments
  • Having more trouble coming up with words than other people the same age

Learn more about Alzheimer’s disease from MedlinePlus.

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Frequently Misplacing Items And Not Being Able To Retrace Steps

Most people will lose items at some time, but they are usually able to locate them again by searching in logical locations and retracing their steps.

However, someone with Alzheimers disease may forget where they placed an item, especially if they put it in an unusual place. They may also be unable to retrace their steps to find the missing item. This can be distressing and cause the person to believe that someone is stealing from them.

Time To Plan For The Future

With an early diagnosis of Alzheimer’s disease, you and your family can have more time to make informed decisions about how you spend time together, as well as important legal and financial plans for the future. It can also help you and your loved one introduce lifestyle changes earlier , implement tools and strategies to help maintain independence longer, build a support network, and make decisions about managing everyday activities, like driving.

For care partners, a loved ones early diagnosis gives you time to slowly adjust to your new role, reducing the impact to your physical and mental well-being.

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Who Gets Early Onset Ad

Although AD isnt an expected part of advancing age, youre at increased risk as you get older. More than 32 percent of people over age 85 have AD.

You may also have an increased risk of developing AD if a parent, sibling, or child has the disease. If more than one family member has AD, your risk increases.

A showed that African Americans, Native Americans, and Native Alaskans are at higher risk for developing early onset AD compared to white people.

Prevalence of early onset AD

Early onset AD affects approximately

The exact cause of early onset AD hasnt been fully determined. Many researchers believe that this disease develops as the result of multiple factors rather than one specific cause.

Researchers have discovered rare genes that may directly cause or contribute to AD. These deterministic genes are:

  • amyloid precursor protein on chromosome 21
  • presenilin-1 on chromosome 14
  • presenilin-2 on chromosome 1

These genes may be carried from one generation to the next within a family. Carrying these genes can result in adults younger than age 65 developing symptoms much earlier than expected.

Mutations in these genes account for only 5 to 10 percent of all Alzheimers cases but a majority of early onset AD cases.

Apolipoprotein E is another gene associated with AD. Its more commonly a factor in people who develop AD after age 65.

Lifestyle changes that help reduce risk include:

  • regular physical activity

What Are The Symptoms Of Early

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For most people with early-onset Alzheimer disease, the symptoms closely mirror those of other forms of Alzheimer disease.

Early symptoms:

  • Withdrawal from work and social situations

  • Changes in mood and personality

Later symptoms:

  • Severe mood swings and behavior changes

  • Deepening confusion about time, place, and life events

  • Suspicions about friends, family, or caregivers

  • Trouble speaking, swallowing, or walking

  • Severe memory loss

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Women Might Be At Higher Risk

Age is the major risk factor for Alzheimers disease, and women on average live longer than men.

However, longevity alone does not fully explain why two-thirds of Alzheimers patients are women. Even after taking into account the difference in longevity, some studies have suggested that women are still at a higher risk.

Subtle Preclinical Changes May Help Target Treatable Disease Stages

byJudy George, Senior Staff Writer, MedPage Today April 22, 2022

Alzheimer’s disease clinical trials are moving toward earlier and earlier intervention, based on the assumption that this may prevent or slow cognitive decline before Alzheimer’s damage occurs. But how early can we detect the cognitive changes associated with Alzheimer’s disease?

“Some of our current clinical instruments are kind of blunt, especially in the preclinical stages of the disease,” said Ron Petersen, MD, PhD, of the Mayo Clinic in Rochester, Minnesota, in an interview with MedPage Today. “Something like the CDR sum of boxes is probably not very useful since most people in those stages would be a CDR zero. Consequently, there’s not a lot of movement on a scale like that.”

Whether specific aspects of cognition are more sensitive to emerging amyloid and tau pathology is something several Alzheimer’s researchers are investigating.

“If amyloid is an important player in the process and we’ve demonstrated some movement at the symptomatic stage of the disease, shouldn’t we go earlier in the preclinical stage?” Petersen noted. “Even then, it might not be a home run but we may have an impact flattening that curve. And then we intervene with other compounds to get at tau, etc., and the complexity of the disease gets chipped away, piece by piece.”

Emerging Pathology and Early Changes

Amyloid Accumulation and Executive Function

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Alzheimers Disease: What You Need To Know As You Age

An estimated 5.2 million Americans are living withAlzheimers disease, the most common form ofdementiain the world and the sixth leading cause of death in the United States.Todays statistics are just the tip of the iceberg, however. By 2025, thenumber of people afflicted will top 7 milliona 40 percent jumpas babyboomers continue to age and people live longer overall.

Although the risk of AD increases with age, it is not a usual partof aging or something that should be expected in older people, saysConstantine Lyketsos, M.D., director of the Memory and Alzheimers Treatment Center at Johns Hopkins.In fact, early onset Alzheimers can occur in people younger than 65,although it accounts for a small number of all cases. The rest areclassified as late onset.

Alzheimers and many other dementias occur as a result of damage toneuronsin the brain that affects their ability to communicate with each other.Over time, those neurons death and malfunction affects memory, learning,mood, behavior, and eventually physical functions, such as walking, andswallowing.

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