Which Medicines Are Used To Treat Alzheimers Disease
There is no cure for Alzheimers disease, but available medications temporarily slow the worsening of dementia symptoms and help with behavioral problems that may appear during the course of the disease.
Four medications representing two drug classes are currently approved by the Food and Drug Administration to treat the symptoms of Alzheimers disease. These drugs are the cholinesterase inhibitors and a NMDA antagonist.
Cholinesterase inhibitors. The cholinesterase inhibitors are all approved to treat the symptoms of mild to moderate Alzheimer’s disease . Cholinesterase inhibitors include:
These drugs work by blocking the action of acetylcholinesterase, the enzyme responsible for destroying acetylcholine. Acetylcholine is one of the chemicals that helps nerve cells communicate. Researchers believe that reduced levels of acetylcholine cause some of the symptoms of Alzheimer’s disease. By blocking the enzyme, these medications increase the concentration of acetylcholine in the brain. This increase is believed to help improve some memory problems and reduce some of the behavioral symptoms seen in patients with Alzheimers disease.
These medications do not cure Alzheimers disease or stop the progression of the disease. The most common side effects of these drugs are nausea, diarrhea, and vomiting. Some people may have loss of appetite, insomnia or bad dreams.
What Does The Research Say
A study by Cao et al. was published in the Journal of Alzheimers Disease in 2014. It looked at the potential therapeutic effects of THC on the disease. The researchers concluded that THC is a possible therapeutic treatment option for AD via various functions and pathways.
One of the key findings of the study was that THC directly interacts with amyloid-beta peptides. As a result, the cannabinoid inhibited aggression. Low doses of THC potentially enhance mitochondria function.
A study by Salk Institute students found that cannabinoids removed plaque-forming Alzheimers proteins from brain cells. The research appeared in a June 2016 edition of Aging and Mechanisms of Disease. The team researched nerve cells altered to produce large amounts of amyloid-beta. The goal was to mimic aspects of Alzheimers.
They found that high levels of plaque were associated with higher rates of neuron death and cellular inflammation. When they exposed the cells to THC, the result was lower amyloid-beta levels. The compound also seemed to eliminate the inflammatory response caused by the protein. As a result, the nerve cells were able to survive.
Can Eating Certain Foods Or Diets Prevent Alzheimer’s Disease
People often wonder if a certain diet or specific foods can help prevent Alzheimer’s disease. The recent NASEM review of research did not find enough evidence to recommend a certain diet to prevent cognitive decline or Alzheimer’s. However, certain diets and healthy eating patterns have been associated with cognitive benefits. Studies of diets, such as the Mediterranean diet and the MIND dieta combination of the Mediterranean and DASH dietsare underway. Learn more about what we know about diet and the prevention of Alzheimer’s disease.
For more information, read What Do We Know About Diet and Alzheimer’s Prevention?
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How Tocontinuously Replenish The Brain With These Essential Nutrients
Our bodies need over 60 essential minerals and traceelements every day to function correctly and at its peak. Exactly how manyminerals our brain needs to function properly, no one really knows. But itslots! Magnesium is one of the most important minerals for the brain and forhealthy nerve function . Studies have shown that dementia sufferers can improve, some quite dramatically in fact, from correct mineral supplementation.
Liquidcolloidal minerals are the best and most absorbable way to get the required 60+minerals your body and brain needs every day . Formagnesium, a transdermal magnesium spray is the best way to go. Magnesium istough for the body to absorb but with a transdermal magnesium spray, itspenetrated directly into the blood stream via the skin. If this is notpractical or you dont like the idea of spraying an oil on your skin every day,there is a terrific magnesium supplement available called Natural Calm, whichis actually one of the very few oral magnesium supplements on the market thatshighly absorbable . You can check it out here if you’re interested NaturalCalm.
Natural Remedies For Dementia And Alzheimers Treatment Option #5: Omega
Omega-3 fatty acids are yet another fat that are incrediblyhealthy for the brain and nervous system. They contain the EPA and DHA essentialfatty acids, which help to prevent brain cell damage and keep the nervoussystem in peak working order. And they dont just help to slow down the progressionof dementia diseases such as Alzheimers and Parkinsons either, theyalso help to lower ones risk of developing the disease in the first place.
Best sources of omega-3s are fish oil, cod liver oil andkrill oil. Krill oil is probably the pick of the bunch because it contains asubstance calledAstaxanthin, which is a potent brain foodand has been shown in studies to help prevent neurodegeneration of the brain.
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Natural Remedies For Dementia And Alzheimers Treatment Option #3: B Groupvitamins Vitamin D And Vitamin E
A study published in Proceedingsof the National Academy of Sciences revealed the B group vitamins, inparticular, vitamin B6, B12 and folic acid, can help slow the progression ofAlzheimers disease. What was stated in the article is quite exciting fordementia sufferers as well as those wanting to prevent the disease
“Thefact that B-family vitamins may play a significant role in dementia, or morespecifically in warding it off has been consistently illustrated. What is newsfrom the current study, however, is that high-dose B-vitamin treatment inpeople at risk for the disease ‘slowed shrinkage of whole brain volume,’ andespecially reduced shrinkage in areas known to be affected in Alzheimer’sdisease.”;
Vitamin B3 and vitamin B6 are needed by the bodyto form neurotransmitters, making them crucial for the health and correctfunctioning of the nervous system and brain. B12 is essential for theproduction of substance known as myelin, the white sheath that surrounds nervefibers. The B group vitamins, especially folic acid, also help to reducehomocysteine levels in the body, another major precursor of dementia anddementia related diseases.
Treatment Of Alzheimer Disease
BRADFORD T. WINSLOW, MD, Swedish Family Medicine Residency, Littleton, Colorado
CHRISTIAN M. STOB, DO, Denver Health Medical Center, Denver, Colorado
KATHLEEN A. HAZLEWOOD, PharmD, University of Wyoming School of Pharmacy, Laramie, Wyoming
Am Fam Physician.;2011;Jun;15;83:1403-1412.
;Patient information: See related handout on Alzheimer disease, written by the authors of this article.
SORT: KEY RECOMMENDATIONS FOR PRACTICE
Acetylcholinesterase inhibitors are modestly effective in patients with mild to moderate Alzheimer disease, although limited by their adverse effects.
|Clinical recommendation||Evidence rating||References|
Combination therapy with an acetylcholinesterase inhibitor and memantine should be considered in patients with moderate to severe Alzheimer disease.
Atypical antipsychotic agents can improve some behavioral manifestations of Alzheimer disease but are associated with increased mortality in older patients.
Nonsteroidal anti-inflammatory drugs, vitamin E, testosterone, estrogen, statins, and insulin sensitizers are not recommended for the treatment of Alzheimer disease.
Physicians should consider discontinuing treatment for Alzheimer disease in patients who continue to decline despite maximal therapy.
SORT: KEY RECOMMENDATIONS FOR PRACTICE
Acetylcholinesterase inhibitors are modestly effective in patients with mild to moderate Alzheimer disease, although limited by their adverse effects.
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Best Sources Of B Group Vitamins Vitamin D And Vitamine
For vitamin B12, a sublingual spray containingmethylcobalamin is the absolute best and most absorbable way to get your dailydose . Heres what one lookslike B12 Sublingual Spray. For the other B group vitamins , a good quality B complex supplement will suffice.
For your vitamin D, there are two ways. Firstly, get outin the sun! 20-40 minutes of regular sun exposure a day is still the best way to receive the vitamin D your body needs. Themost important areas of exposure are the face and back of the hands. Inaddition to this, and especially if you live in cold climates, supplementationwith vitamin D3 is crucial. Best sources arevitamin D3 supplements and cod liver oil. Just remember too, our bodys needlots of vitamin D so dont be afraid of overdosing on this vital nutrient.
For vitamin E, the best source is without a doubtunprocessed red palm oil. The benefit of red palm oil is not only is itincredibly high in the eight different forms of molecules categorized as vitaminE , its also high in thehealthy ketone fats all dementia sufferers need. And in addition, red palm oil helps with blood circulation, along withproviding powerful neuroprotection just for good measure!
Even Dr Oz says red palm oil is a miracle oil forlongevity so start getting some into you or your loved one as soon as you can.
Targets Of Alzheimer’s Disease Prevention Research
Researchers are exploring these and other interventions that may help prevent, delay, or slow Alzheimer’s dementia or age-related cognitive decline. Other research targets include:
- New drugs to delay onset or slow disease progression
- Diabetes treatment
- Blood pressure- and lipid-lowering treatments
- Sleep interventions
- Vitamins such as B12 plus folic acid supplements and D
- Combined physical and mental exercises
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Effects Of Cholinesterase Inhibitors
People with Alzheimers may find that their symptoms improve by taking a cholinesterase inhibitor. This could be improvement in thinking, memory, communication or with day-to-day activities. Others may find that their condition stays the same, or that their symptoms do not worsen as quickly as they would have expected. Some people may not notice any effect at all.
As these drugs dont stop the disease from progressing in the brain, symptoms will continue to get worse over time. However, they can help some people to function slightly better than they would do without the drug.
The most common side-effects of cholinesterase inhibitors are feeling or being sick, diarrhoea, having trouble sleeping, muscle cramps and tiredness. These effects are often mild and usually only temporary. Not everyone will experience side-effects. If you are worried about side-effects you can talk about this with your doctor.
Medications For Cognitive Symptoms
No disease-modifying drugs are available for Alzheimers disease, but some options may reduce the symptoms and help improve quality of life.
Drugs called cholinesterase inhibitors can ease cognitive symptoms, including memory loss, confusion, altered thought processes, and judgment problems. They improve neural communication across the brain and slow the progress of these symptoms.
Three common drugs with Food and Drug Administration approval to treat these symptoms of Alzheimers disease are:
- donepezil , to treat all stages
- galantamine , to treat mild-to-moderate stages
- rivastigmine , to treat mild-to-moderate stages
Another drug, called memantine , has approval to treat moderate-to-severe Alzheimers disease. A combination of memantine and donepezil is also available.
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Practical Tips On Medications To Manage Difficult Behaviors In Dementia
You may be now wondering just how doctors are supposed to manage medications for difficult dementia behaviors.
Here are the key points that I usually share with families:
- Before resorting to medication: its essential to try to identify what is triggering/worsening the behavior, and its important to try non-drug approaches, including exercise.
- Be sure to consider treating possible pain or constipation, as these are easily overlooked in people with dementia. Geriatricians often try scheduling acetaminophen 2-3 times daily, since people with dementia may not be able to articulate their pain. We also titrate laxatives to aim for a soft bowel movement every 1-2 days.
- No type of medication has been clinically shown to improve behavior for most people with dementia. If you try medication for this purpose, you should be prepared to do some trial-and-error, and its essential to carefully monitor how well the medication is working and what side-effects may be happening.
- Antipsychotics and benzodiazepines work fairly quickly, but most of the time they are working through sedation and chemical restraint. They tend to cloud thinking further. It is important to use the lowest possible dose of these medications.
- Antidepressants take a while to work, but are generally well-tolerated. Geriatricians often try escitalopram or citalopram in people with dementia.
What Is Alzheimer’s Disease
Alzheimers disease is a brain disorder that cannot be stopped or reversed. The disease severely affects memory, thinking, learning and organizing skills and eventually affects a persons ability to carry out simple daily activities. Alzheimers disease is not a normal part of the aging process.
Alzheimers is a disease whose symptoms worsen over time. In fact, scientists believe the disease process may go on for 10 years or longer before the first symptoms of Alzheimers disease appear.
When memory problems do begin to be noticeable, they are often identified as mild cognitive impairment . At this stage, intellectual function is affected but the ability to function and live independently remain intact as the brain compensates for disease-related changes.
In some people, MCI can hold steady at this stage. However, people with MCI are at high risk for progressing to dementia. Alzheimers disease is the most common form of dementia. With dementia, in contrast to MCI, daily function is affected.
As dementia due to Alzheimers disease progresses to late stages, affected individuals cannot carry on a conversation, recognize family and friends, or care for themselves.
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Get The Best Stem Cell Treatment Clinics For Alzheimers Disease In The Czech Republic
There are a lot of;centers that offer Stem cell treatment in the Czech Republic;to choose from. Before undergoing this type of procedure, one must pick a reputable facility that is able to provide Alzheimers Disease treatment at its best. These centers typically should be known to perform a significant number of successful similar treatment procedures, have highly trained staff and known specialization in Stem cell treatment. They should also have up-to-date equipment for a smooth and successful procedure.
Whats New In The Alzheimers Treatment Pipeline
The search for new medications that are both safe and effective weapons in the fight against Alzheimers disease has already demanded the collaboration of thousands of researchers and hundreds of thousands of willing subjects. But it is far from over! Since 1998, 146 drugs have been tested and rejected. Only four drugs have made it through the rigorous clinical trial process that precedes approval by the Food and Drug Administration . The approved drugs have modest symptom-reducing effects, but they do not alter the eventual course of Alzheimers disease.
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Can Controlling High Blood Pressure Prevent Alzheimer’s Disease
Controlling high blood pressure is known to reduce a person’s risk for heart disease and stroke. The NASEM committee of experts concluded that managing blood pressure when it’s high, particularly for middle-aged adults, also might help prevent or delay Alzheimer’s dementia.
Many types of studies show a connection between high blood pressure, cerebrovascular disease , and dementia. For example, it’s common for people with Alzheimer’s-related changes in the brain to also have signs of vascular damage in the brain, autopsy studies show. In addition, observational studies have found that high blood pressure in middle age, along with other cerebrovascular risk factors such as diabetes and smoking, increase the risk of developing dementia.
Clinical trialsthe gold standard of medical proofare underway to determine whether managing high blood pressure in individuals with hypertension can prevent Alzheimer’s dementia or cognitive decline.
One large clinical trialcalled SPRINT-MIND found that lowering systolic blood pressure to less than 120 mmHg, compared to a target of less than 140 mmHg, did not significantly reduce the risk of dementia. Participants were adults age 50 and older who were at high risk of cardiovascular disease but had no history of stroke or diabetes.
What Does The Stem Cell Treatment Package For Alzheimers Disease In The Czech Republic Should Include
The;packages for Stem cell treatment for Alzheimers Disease in the Czech Republic;vary depending on the center. Generally, these costs include the actual treatment procedure, fees of the hospital, medicines, the doctor, and nurse. It may not cover other expenses like accommodation, food, and transportation from the airport for some packages. It is best to understand well the specifics of your package to anticipate expenses accordingly.
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What Everyone Can Do Today
I am hopeful that this medication will work to slow Alzheimers and reduce the suffering it causes individuals and their families. We should remember that the other FDA-approved medications for Alzheimers can also be helpful , as can controlling blood pressure, engaging in aerobic exercise, eating a Mediterranean menu of foods, staying socially active, keeping a positive attitude, and using memory strategies.
Search The Right Expert Or Doctor For Stem Cell Treatment For Alzheimers Disease In The Czech Republic
There are many;reliable;doctors for Stem cell treatment for Alzheimers Disease in the Czech Republic;with extensive experience and knowledge. They should have certifications and accreditations from credible institutions to back up their qualifications. Having affiliations with local and international bodies would also reflect the expertise and experience that the doctor has on your treatment.
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How Much Does It Cost And How Soon Can I Get It
Biogen, the company that makes aducanumab, estimates its cost at $56,000 per year. It is not yet clear whether Medicare, Medicaid, or private insurance companies will pay for this medication. In its press release, Biogen noted that they are working on an agreement with the Veterans Health Administration to cover this medication for veterans enrolled in VA healthcare. Aducanumab is not currently available, but the company is working to make the drug available quickly, perhaps in a few months.