Personal Life And Death
In 1894, Alzheimer married Cecilie Simonette Nathalie Geisenheimer, with whom he had three children. Geisenheimer died in 1901.
In August 1912, Alzheimer fell ill on the train on his way to the University of Breslau, where he had been appointed professor of psychiatry in July 1912. Most probably he had a streptococcal infection and subsequent rheumatic fever leading to valvular heart disease, heart failure and kidney failure. He did not recover completely from this illness.
Health Environmental And Lifestyle Factors
Research suggests that a host of factors beyond genetics may play a role in the development and course of Alzheimers. There is a great deal of interest, for example, in the relationship between cognitive decline and vascular conditions such as heart disease, stroke, and high blood pressure, as well as conditions such as diabetes and obesity. Ongoing research will help us understand whether and how reducing risk factors for these conditions may also reduce the risk of Alzheimers.
A nutritious diet, physical activity, social engagement, and mentally stimulating pursuits have all been associated with helping people stay healthy as they age. These factors might also help reduce the risk of cognitive decline and Alzheimers. Researchers are testing some of these possibilities in clinical trials.
What Is The Burden Of Alzheimers Disease In The United States
- Alzheimers disease is one of the top 10 leading causes of death in the United States.2
- The 6th leading cause of death among US adults.
- The 5th leading cause of death among adults aged 65 years or older.3
In 2020, an estimated 5.8 million Americans aged 65 years or older had Alzheimers disease.1 This number is projected to nearly triple to 14 million people by 2060.1
In 2010, the costs of treating Alzheimers disease were projected to fall between $159 and $215 billion.4 By 2040, these costs are projected to jump to between $379 and more than $500 billion annually.4
Death rates for Alzheimers disease are increasing, unlike heart disease and cancer death rates that are on the decline.5 Dementia, including Alzheimers disease, has been shown to be under-reported in death certificates and therefore the proportion of older people who die from Alzheimers may be considerably higher.6
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What Are Some Risk Factors For Alzheimers Disease
Risk factors for the development of Alzheimers disease include:
- Age. Increasing age is the primary risk factor for developing Alzheimers disease.
- Genetics . There is a certain gene, apolipoprotein E that is associated with late-onset Alzheimers disease. Other genes have been associated with early-onset Alzheimers disease.
Researchers believe the presence of the last five risk factors mentioned above might reduce the clearance of amyloid protein from the brain, which then increases the risk of developing Alzheimers disease. In particular, the presence of a number of these risk factors at the same time and while the person is in his or her 50s is associated with a higher risk of Alzheimers disease.
There may be some ways to reduce the risk of mental decline. In general, living a healthy lifestyle protects the body from strokes and heart attacks and is believed to also protect the brain from cognitive decline. Scientists cant absolutely prove the cause and effect of the following factors, but studies have shown a positive association.
The Effects Of Alzheimers On The Brain
Damage to the brain begins years before symptoms appear. Abnormal protein deposits form plaques and tangles in the brain of someone with Alzheimers disease. Connections between cells are lost, and they begin to die. In advanced cases, the brain shows significant shrinkage.
Its impossible to diagnose Alzheimers with complete accuracy while a person is alive. The diagnosis can only be confirmed when the brain is examined under a microscope during an autopsy. However, specialists are able to make the correct diagnosis up to 90 percent of the time.
The symptoms of Alzheimers and dementia can overlap, but there can be some differences.
Both conditions can cause:
- behavioral changes
- difficulty speaking, swallowing, or walking in advanced stages of the disease
Some types of dementia will share some of these symptoms, but they include or exclude other symptoms that can help make a differential diagnosis. Lewy body dementia , for example, has many of the same later symptoms as Alzheimers. However, people with LBD but are more likely to experience initial symptoms such as visual hallucinations, difficulties with balance, and sleep disturbances.
People with dementia due to Parkinsons or Huntingtons disease are more likely to experience involuntary movement in the early stages of the disease.
Treatment for dementia will depend on the exact cause and type of dementia, but many treatments for dementia and Alzheimers will overlap.
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Symptoms Specific To Frontotemporal Dementia
Although Alzheimer’s disease is still the most common type of dementia in people under 65, a higher percentage of people in this age group may develop frontotemporal dementia than older people. Most cases are diagnosed in people aged 45-65.
Early symptoms of frontotemporal dementia may include:
- personality changes reduced sensitivity to others’ feelings, making people seem cold and unfeeling
- lack of social awareness making inappropriate jokes or showing a lack of tact, though some people may become very withdrawn and apathetic
- language problems difficulty finding the right words or understanding them
- becoming obsessive such as developing fads for unusual foods, overeating and drinking
Read more about frontotemporal dementia.
Icipating In Alzheimer’s Disease Clinical Trials
Everybody those with Alzheimers disease or MCI as well as healthy volunteers with or without a family history of Alzheimers may be able to take part in clinical trials and studies. Participants in Alzheimers clinical research help scientists learn how the brain changes in healthy aging and in Alzheimers. Currently, at least 270,000 volunteers are needed to participate in more than 250 active clinical trials and studies that are testing ways to understand, diagnose, treat, and prevent Alzheimers disease.
Volunteering for a clinical trial is one way to help in the fight against Alzheimers. Studies need participants of different ages, sexes, races, and ethnicities to ensure that results are meaningful for many people.
NIA leads the federal governments research efforts on Alzheimers. NIA-supported Alzheimers Disease Research Centers throughout the U.S. conduct a wide range of research, including studies of the causes, diagnosis, and management of the disease. NIA also sponsors the Alzheimers Clinical Trials Consortium, which is designed to accelerate and expand studies and therapies in Alzheimers and related dementias.
To learn more about Alzheimers clinical trials and studies:
- Talk to your health care provider about local studies that may be right for you.
Watch videos of participants in Alzheimers disease clinical trials talking about their experiences.
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Signs And Symptoms Of Alzheimer’s Disease
Memory problems are typically one of the first signs of cognitive impairment related to Alzheimers. Some people with memory problems have a condition called mild cognitive impairment . With MCI, people have more memory problems than normal for their age, but their symptoms do not interfere with their everyday lives. Movement difficulties and problems with the sense of smell have also been linked to MCI. Older people with MCI are at greater risk for developing Alzheimers, but not all of them do so. Some may even revert to normal cognition.
The first symptoms of Alzheimers vary from person to person. For many, decline in nonmemory aspects of cognition, such as word-finding, vision/spatial issues, and impaired reasoning or judgment may signal the very early stages of the disease. Researchers are studying biomarkers to detect early changes in the brains of people with MCI and in cognitively normal people who may be at greater risk for Alzheimers. More research is needed before these techniques can be used broadly and routinely to diagnose Alzheimers in a health care providers office.
Alzheimer’s Disease: The Progress Of Naming
Alzheimer’s Disease is named after the widely known doctor who focused on the study of neurosyphilis and vascular dementia. He reported the first case to the academic world. As Alzheimer’s disease is common in contemporary medicine, the origin and progress of naming, Alzheimer’s Disease, are described in detail.,,,,,,,
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Forgetting How To Do Everyday Tasks
This is different to: more typical age-related forgetfulness such as needing help to record a tv programme or how to use the settings on a microwave oven.
Your parent may start to find it hard to complete daily tasks these might include the setting of a table, driving to a familiar location or remembering the rules of their favourite game.
Forgetting how to do everyday tasks is one of the signs of dementia and can be spotted in-person or by completing a Self-Administered Gerocognitive Exam an early signs of dementia test which can be taken online.
However, this shouldnt be used as an official diagnostic tool you should always seek the advice of a GP. Other examples of forgetting how to do simple everyday tasks can include:
- Closing the fridge door
- Making a cup of tea or coffee
- Locking / closing the front door
- Managing a budget
Your parent may start to find it difficult to complete tasks they used to be able to do with ease. For example, if they used to be a fantastic baker, they may now find it hard to bake the sponge cake theyve made over and over again.
Putting Things In The Wrong Place
This is different to: more normal age-related behaviours such as losing things but being able to retrace the steps to find them.
Losing things or putting things in strange places, and then being unable to retrace steps to find them again, is on the official observation list for early signs of dementia.
Sometimes someone else might be accused of stealing which may occur more frequently over time. For example, your dad may insist that a friend keeps stealing his money, whereas its in its regular hiding place.
Other examples that may indicate potential dementia symptoms could include:
- Teabags in the fridge and leaving the milk out
- Toothbrush in the washing basket
- Remote control in the cutlery drawer
- Dirty laundry in the dishwasher
Misplacing or losing items is more common in Alzheimers Disease, rather than vascular dementia. Find out more about the different types of dementia.
Stage : Very Mild Decline
The senior may notice minor memory problems or lose things around the house, although not to the point where the memory loss can easily be distinguished from normal age-related memory loss. The person will still do well on memory tests and the disease is unlikely to be detected by loved ones or physicians.
Symptoms Specific To Vascular Dementia
Vascular dementia is the second most common cause of dementia, after Alzheimer’s. Some people have both vascular dementia and Alzheimer’s disease, often called “mixed dementia”.
Symptoms of vascular dementia are similar to Alzheimer’s disease, although memory loss may not be as obvious in the early stages.
Symptoms can sometimes develop suddenly and quickly get worse, but they can also develop gradually over many months or years.
Specific symptoms can include:
- stroke-like symptoms: including muscle weakness or temporary paralysis on one side of the body
- movement problems difficulty walking or a change in the way a person walks
- thinking problems having difficulty with attention, planning and reasoning
- mood changes depression and a tendency to become more emotional
Read more about vascular dementia.
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Stage : Moderately Severe Decline
During the fifth stage of Alzheimers, people begin to need help with many day-to-day activities. People in stage five of the disease may experience:
- Difficulty dressing appropriately
- Inability to recall simple details about themselves such as their own phone number
- Significant confusion
On the other hand, people in stage five maintain functionality. They typically can still bathe and toilet independently. They also usually still know their family members and some detail about their personal histories, especially their childhood and youth.
What Newer Medications Are Under Study
All currently approved medications target Alzheimers disease after it develops. Scientists are currently researching ways to stop or slow the progress of Alzheimers disease before it starts.
Some of the drugs in late-stage investigation are called monoclonal antibodies. These drugs target the amyloid protein that builds up in brain cells. They work by attaching to the amyloid proteins as they float in the brain and remove them, before they form into the plaques and tangles that interfere with the brains ability to properly function.
These drugs are still in clinical trials and are several years away from Food and Drug Administration approval in the United States. Early results have been mixed, with some trials showing no improvement in brain function others showing a slight improvement . Despite the mixed results, researchers are excited about this new potential method to modify the disease process.
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How Is Alzheimers Disease Treated
Alzheimers is complex, and it is therefore unlikely that any one drug or other intervention will successfully treat it in all people living with the disease.
Scientists are exploring many avenues to delay or prevent the disease as well as to treat its symptoms. In ongoing clinical trials, scientists are developing and testing several possible interventions. Under study are drug therapies aimed at a variety of disease interventions, as well as nondrug approaches such as physical activity, diet, cognitive training, and combinations of these. Just as we have many treatments for heart disease and cancer, we will likely need many options for treating Alzheimers. Precision medicine getting the right treatment to the right person at the right time will likely play a major role.
Current approaches to treating Alzheimers focus on helping people maintain mental function, treating the underlying disease process, and managing behavioral symptoms.
Symptoms Specific To Dementia With Lewy Bodies
Dementia with Lewy bodies has many of the symptoms of Alzheimer’s disease, and people with the condition typically also experience:
- periods of being alert or drowsy, or fluctuating levels of confusion
- visual hallucinations
- becoming slower in their physical movements
- repeated falls and fainting
Read more about dementia with Lewy bodies.
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Throughout History Many Terms Used To Describe Dementia
by Patient Advocate
Dad gets three different daily newspapers, so I’m always skimming them to see if I can find something interesting to share. One of the stories this morning described the Acosta family of Austin, TX. The story noted that the first identification of the disease was in 1982 when it attacked a mother of three young daughters. The mother was initially diagnosed with mad cow disease, but instead she had a rare, inherited form of Alzheimer’s disease. Now two of the three daughters also have the same condition. One is 48, while the other is 38. Both of these sisters are in the process of losing their memory.
It’s a horrific story, especially when thinking of the ages of these women as they battle this brain disease. But the other piece I found that was interesting was the misdiagnosis. That got me thinking about my own family tree. I had noticed that there a number of diagnoses showing up in my maternal genealogical records that actually seemed to indicate that relatives had some form of dementia. For instance, some relatives were described as being senile. describes “senility” as “the quality or state of being senile specifically: the physical and mental infirmity of old age.”
So if you’re searching your family history for this condition, what should you look for? We’re in luck because the Michigan Family History Network offers some other medical terms that were used in old records for dementia. These include:
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Early Life And Education
The Alzheimers moved to Aschaffenburg when Alois was still young in order to give their children an opportunity to attend the Royal Humanistic Gymnasium. After graduating with Abitur in 1883, Alzheimer studied medicine at University of Berlin, University of Tübingen, and University of Würzburg. In his final year at university, he was a member of a fencing fraternity, and even received a fine for disturbing the peace while out with his team. In 1887, Alois Alzheimer graduated from Würzburg as Doctor of Medicine.
What Are The Warning Signs Of Alzheimers Disease
Watch this video play circle solid iconMemory Loss is Not a Normal Part of Aging
Alzheimers disease is not a normal part of aging. Memory problems are typically one of the first warning signs of Alzheimers disease and related dementias.
In addition to memory problems, someone with symptoms of Alzheimers disease may experience one or more of the following:
- Memory loss that disrupts daily life, such as getting lost in a familiar place or repeating questions.
- Trouble handling money and paying bills.
- Difficulty completing familiar tasks at home, at work or at leisure.
- Misplacing things and being unable to retrace steps to find them.
- Changes in mood, personality, or behavior.
Even if you or someone you know has several or even most of these signs, it doesnt mean its Alzheimers disease. Know the 10 warning signs .
When Someone You Love Has Alzheimer Disease
You might feel sad or angry or both if someone you love has Alzheimer disease. You might feel nervous around the person, especially if he or she is having trouble remembering important things or can no longer take care of himself or herself.
You might not want to go visit the person, even though your mom or dad wants you to. You are definitely not alone in these feelings. Try talking with a parent or another trusted adult. Just saying what’s on your mind might help you feel better. You also may learn that the adults in your life are having struggles of their own with the situation.
If you visit a loved one who has Alzheimer disease, try to be patient. He or she may have good days and bad days. It can be sad if you can’t have fun in the same ways together. Maybe you and your grandmother liked to go to concerts. If that’s no longer possible, maybe bring her some wonderful music and listen together. It’s a way to show her that you care and showing that love is important, even if her memory is failing.
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