Alzheimers Trigger Discovered Disease Mutations Impact How Brain Cells Produce Energy
ADELAIDE, Australia Finding the cause of Alzheimers disease may eventually lead to a cure for the worlds most common form of dementia. A new study may have discovered that critical trigger, finding a link between genetic mutations in Alzheimers patients and the way a persons cells produce energy.
A team from the University of Adelaide found that different mutations in a persons genes impact different cell functions in different ways. However, various mutations related to Alzheimers seem to affect cells in the same way disrupting how they use oxygen to create energy.
How Does Alzheimers Impact Life Expectancy
According to a study, the key factors that determine how long someone lives after being diagnosed with Alzheimer’s disease and other forms of dementia are gender, age, and level of disability:
- While men lived approximately 4.1 years following diagnosis, women lived approximately 4.6 years.
- When someone who is over the age of 90 is diagnosed with Alzheimer’s disease, they live 3.8 years. In contrast, someone under the age of 70 lived 10.7 years.
- If a patient was frail when they were diagnosed, they didn’t live as long even after the adjustment for age has been made.
In the end, the average survival time for those diagnosed with Alzheimer’s disease and other forms of dementia was 4.5 years.
How To Improve A Loved One’s Quality Of Life After Diagnosis
While there is no cure for Alzheimer’s disease, there are activities and therapies designed to improve your loved ones quality of life. For example, the extent to which your loved one with Alzheimer’s disease can maintain their social relationships may play a large role.
At home, it’s important to try to maintain as much normalcy as possible. In particular, it can be helpful for your loved one to maintain their household responsibilities. In the later stages of the disease, your loved one’s needs are likely to change, and it’s critical for you as a caregiver to know how to care for yourself as well as your loved one.
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What Are The 7 Stages Of Dementia
People with dementia have problems with thinking, memory, and reasoning, and lose the ability to carry out tasks of daily living. They may also experience changes in personality, mood, and behavior. Dementia is typically defined in seven stages. Alzheimers disease is the most common form of dementia.
Stage : Moderate Dementia
Patients in stage 5 need some assistance in order to carry out their daily lives. The main sign for stage 5 dementia is the inability to remember major details such as the name of a close family member or a home address. Patients may become disoriented about the time and place, have trouble making decisions, and forget basic information about themselves, such as a telephone number or address.
While moderate dementia can interfere with basic functioning, patients at this stage do not need assistance with basic functions such as using the bathroom or eating. Patients also still have the ability to remember their own names and generally the names of spouses and children.
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Can Dementia Get Worse Suddenly
Dementia is a progressive condition, meaning that it gets worse over time. The speed of deterioration differs between individuals. Age, general health and the underlying disease causing brain damage will all affect the pattern of progression. However, for some people the decline can be sudden and rapid.
How Fast Does Mild Cognitive Impairment Progress
Mild cognitive impairment does not have a fixed rate of progress. Some persons may have a few years of a window before they are diagnosed for Alzheimers. Others may have even longer or maybe never ever get diagnosed for Alzheimers or dementia. Some people may have only mild cognitive impairment even after they are 10 years into the condition.
To get a clear picture about how fast mild cognitive impairment will progress to the next extent, it is better to go for imaging scans which will depict how much beta- amyloid and tau is collected in the persons brain. However, insurance does not cover these tests and many doctors prefer not to advise these tests for a mild cognitive impairment patient, it is best achieved by joining clinical trials. Alzheimers witnesses an accumulation of beta amyloid plaques or tau triangles in the brain. If the cognitive impairment symptoms also worsen along with these proteins getting deposited, and this is confirmed by the imaging scans, it can be said that the mild cognitive impairment is progressing into Alzheimers or dementia.
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Stage : Moderately Severe Cognitive Declinemoderate Dementia
In this stage, deficits are of sufficient magnitude as to prevent catastrophe-free, independent community survival. The characteristic functional change in this stage is early deficits in basic activities of daily life. This is manifest in a decrement in the ability to choose the proper clothing to wear for the weather conditions or for everyday circumstances. Some persons with Alzheimers disease begin to wear the same clothing day after day unless reminded to change. The mean duration of this stage is 1.5 years.
The person with Alzheimers disease can no longer manage on their own. There is generally someone who is assisting in providing adequate and proper food, as well as assuring that the rent and utilities are paid and the finances are taken care of. For those who are not properly supervised, predatory strangers may become a problem. Very common reactions for persons at this stage who are not given adequate support are behavioral problems such as anger and suspiciousness.
Cognitively, persons at this stage frequently cannot recall major events and aspects of their current life such as the name of the current head of state, the weather conditions of the day, or their correct current address. Characteristically, some of these important aspects of current life are recalled, but not others. Also, the information is loosely held, so, for example, the person with moderate Alzheimers disease may recall their correct address on certain occasions, but not others.
Which Is The Fastest Progressing Form Of Dementia
How Fast Does Dementia Progress? It is important to note that dementia progresses at different speeds for every person, and for different types of dementia. The most well-known form of dementia, Alzheimers disease, is just one specific type of dementia, and tends to have the slowest progression of all types.
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Using The Gds To Measure Dementia Progression
As the disease progresses, different signs and symptoms will become increasingly obvious. While there are several scales to measure the progression of dementia, the most common scale is the Global Deterioration Scale for Assessment of Primary Degenerative Dementia . The scale is also known as the Reisberg Scale. According to the GDS, there are seven different stages of Alzheimers disease correlating with four distinct categories: no Alzheimers, mild Alzheimers , moderate Alzheimers , and severe Alzheimers .
What Is Primary Progressive Aphasia Dementia
Primary progressive aphasiadementia
How long does someone live with primary progressive aphasia?
People who have the disease typically live about 3-12 years after they are originally diagnosed. In some people, difficulty with language remains the primary symptom, while others may develop additional problems including cognitive or behavioral changes or difficulty coordinating movements.
how does primary progressive aphasia progress?Primary progressive aphasiaprogressive
How Long Will You Live After A Dementia Diagnosis
Its sad but true that people with dementia usually have shorter lives. However, exactly how much shorter their life will vary enormously from person to person. Heres the key information about life expectancy, but remember, these are only general statistics so think carefully about whether you want to know before you read on.
The Progression Of Dementia
Many types of dementia exist. They are all progressive.
As the disease progresses, the structure and chemistry of the brain become damaged. This leads to the following:
- Problems with short and long term memory
- Inability to clearly communicate
How fast these effects appear depends on the individual. Each dementia sufferer is unique. The disease progresses depending on factors that no two people share. For example, the rate of progression of dementia often relies upon:
- The physical make-up of the person
- The emotional resilience of the person
- Medication prescribed
- Medical conditions he has had over the years
- The support the person has around him
As dementia progresses, sufferers need more support, especially with daily living skills. Since behavior and mood changes with the later stages of the disease, many family members find it difficult to continue providing care.
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What Are Specific Care Needs At Each Stage
An individual may not require care assistance after the initial diagnosis of dementia, but that will change as the disease progresses and symptoms become worse. There are about 16 million unpaid caregivers of people with dementia in the United States. While many caregivers are providing daily help for family members, they also hire someone to help. There are many options of care assistance, such as in-home care, adult day care, and nursing home care. There is also financial assistance available.
Early Stage DementiaAs mentioned above, in the early stage of dementia a person can function rather independently and requires little care assistance. Simple reminders of appointments and names of people may be needed. Caregivers can also assist with coping strategies to help loved ones remain as independent as possible, such as writing out a daily to-do list and a schedule for taking medications. Safety should always be considered, and if any tasks cannot be performed safely alone, supervision and assistance should be provided. During this period of dementia, its a good idea for caregivers and loved ones to discuss the future. For example, a long-term care plan should be made and financial and legal matters put in place.
The 7 Stages Of Dementia
Alzheimers disease and other common forms of dementia including vascular dementia, dementia with Lewy bodies, and frontotemporal dementia are progressive conditions, with symptoms worsening over time as the disease progresses. Learn more about the stages of dementia and what to expect from your loved one as dementia progresses.
Although the two terms are often used interchangeably, Alzheimers disease and dementia are two different terms. Dementia is an umbrella term used to describe several conditions and it includes Alzheimers, as well as other conditions with shared symptoms. More than mere forgetfulness, an individual must have trouble with at least two of the following cognitive areas to be diagnosed with dementia:
- Reasoning and judgment
- Visual perception
The assessment tools used to determine which stage of dementia a person is experiencing are meant to be a guide and a rough outline of what caregivers can expect and when they can expect it. Some symptoms may occur later than others, others may appear in a different order than the scale predicts, and some may not appear at all. Some symptoms may appear and then vanish, while others will continue to worsen over time. Because every person is different and dementia manifests itself uniquely, the speed at which dementia progresses varies widely. On average, a person with Alzheimers disease lives 4 to 8 years after a diagnosis, but some have been seen to live as long as 20 years.
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Life Expectancy By Stage Of The Disease
The average number of years a person lives with Alzheimers disease is about 10. Keep in mind, however, that theres a gap between when symptoms begin and when a diagnosis is actually sought. The first symptoms of Alzheimers diseaseforgetting names, misplacing items, difficulty concentrating at work or performing simple tasksarrive an average of almost three years before the diagnosis is made.
The scale most commonly used by health professionals for the stages of dementia is the Global Deterioration Scale , also called the Reisberg Scale. The table below shows a patients average life expectancy by the stage of dementia. These are averages based on studies of large numbers of Alzheimers patients.
|Life Expectancy By Stage of Alzheimers / Dementia|
|Stage 7: Very Severe Cognitive Decline||1.5 to 2.5 years||2.5 years or less|
How Dementia Progresses
Find out more about the way dementia progresses, including what to expect at different stages of the condition.
All types of dementia are progressive. This means that the structure and chemistry of the brain become increasingly damaged over time.
How quickly dementia progresses depends on the individual. Each person is unique and experiences dementia in their own way. This can depend on many factors, including physical make-up, emotional resilience and the support available to them.
Viewing dementia as a series of stages can be a useful way to understand the illness, but it is important to realise that this only provides a rough guide to the progress of the condition.
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What Happens In Rpd
The progression of RPD varies from patient to patient and in part depends on the underlying cause. Patients typically develop problems with their thinking, mood/personality/behavior, ability to speak or understand, or ability to control their movements. Many are often treatable and reversible if diagnosed quickly. For some other RPDs, there are no cures, and the progression of symptoms is inevitable. There may be some treatment to help relieve specific symptoms. Patients with non-curable forms of RPD may die within months or a few years from onset.
Mild Alzheimers Or Moderate Decline
Stage 4 lasts about two years and marks the beginning of diagnosable Alzheimers disease. You or your loved one will have more trouble with complex but everyday tasks. Mood changes such as withdrawal and denial are more evident. Decreased emotional response is also frequent, especially in a challenging situation.
New signs of decline that appear in stage 4 may include:
- losing memory of personal history
- trouble with handling finances and bills
- inability to count backward from 100 by 7s
A clinician will also look for a decline in areas mentioned in stage 3, but theres often no change since then.
Caregiver support: Itll still be possible for someone to recall weather conditions, important events, and addresses. But they may ask for help with other tasks such as writing checks, ordering food, and buying groceries.
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Stage : Very Mild Cognitive Decline
Stage 2 can vary between typical age-related memory problems that most seniors face, such as forgetting specific dates or slower recall of a name or word. Or this stage could include some of the beginning signs of dementia that are often not obvious to doctors and loved ones. Some of the side effects that correspond with stage 2 include:
- Forgetting everyday phrases or names
- Forgetting the location of important objects
Evidence That Life Expectancy Calculators For Dementia Actually Work
It turns out that the length of time a person has before needing full-time care, before moving into a care community, and before dying can all be predicted somewhat accurately. This information, though not definitive, can help families get a general understanding of how to plan for the future and what to expect as the disease progresses.
In a study conducted at the department of neurology in Columbia University, groups of people with mild Alzheimers were followed for 10 years and assessed semiannually. Data from these assessments were plugged into a complicated algorithm. The people studied were tested for the following:
Mental status score Cognition and function Motor skills Psychology and behavior Basic demographic information
Other experiments have yielded similar results. A University of Kentucky study analyzed the records of more than 1,200 people with dementia and found that it was possible to accurately predict their life expectancy. Researchers looked at many variables including family history and medical problems like high blood pressure and heart disease, and ultimately realized it came down to three things:
age when the first symptoms appeared gender how impaired someone was when diagnosis was first made
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Why Might Dementia Progress Quickly
Alzheimers disease typically has a slow and gradual progression, whereas people affected by vascular dementia tend to show periodic, step-wise impairments in function. However, many factors have an impact on the development of dementia. An individuals genetic heritage will play a role, as does their general, physical health. People with cardiovascular disease or diabetes, especially if they are poorly controlled, are at risk of a faster deterioration. People who are frail with low immunity and recurrent infections are also vulnerable. Young-onset dementia tends to progress more rapidly. People who develop dementia between the ages of thirty and fifty, appear to live two years less than those whose dementia is diagnosed later in life.
Most cases of sudden confusion and rapidly progressing dementia in an elderly person are due to delirium caused by infection. Urinary infections and pneumonia can trigger acute confusion that comes on quickly, causing people to be incoherent, muddled and disorientated. Agitation, aggression and odd behaviour are also common. The good news is that the symptoms of delirium can be reversed when the infection is appropriately treated.
Stage : Normal Outward Behavior
Alzheimerâs disease usually starts silently, with brain changes that begin years before anyone notices a problem. When your loved one is in this early phase, they wont have any symptoms that you can spot. Only a PET scan, an imaging test that shows how the brain is working, can reveal whether they have Alzheimers.
As they move into the next six stages, your friend or relative with Alzheimers will see more and more changes in their thinking and reasoning.
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