New Ways To Detect Alzheimers Disease
The biggest advance toward the early prediction of Alzheimer’s, Hartley says, is using PET scans to show the buildup of beta amyloid plaques in the brain. The plaques are a risk factor for the disease, and in the past they could be seen only during an autopsy.
This is an opportunity to see into the live brain, Hartley says.
The FDA has approved PET amyloid imaging for use in some clinical trials and to help diagnose dementia patients, but not to predict the development of the disease — at least not yet.
PET imaging with amyloid will be the first way of approaching prediction, Apostolova says. MRI will also be useful, she says, as will PET imaging for tau proteins, another sign of disease.
But, she continues, amyloid PET scans are expensive, not readily available, and they expose patients to radiation.
What if theres another way to get at the answer of whos at risk? she asks.
Research Apostolova led while at UCLA resulted in a simple blood test that picks up biomarkers — or proteins in the blood — linked to Alzheimers. Along with other tests, it one day may help predict the disease. She published her early findings in January in the journal Neurology.
Researchers are studying several other new tests:
All of these tests remain experimental, and their effectiveness remains to be seen.
Saliva tests, blood tests, and things like that are not ready for prime time, Hartley says.
Putting Things In The Wrong Place
This is different to: more normal age-related behaviours such as losing things but being able to retrace the steps to find them.
Losing things or putting things in strange places, and then being unable to retrace steps to find them again, is on the official observation list for early signs of dementia.
Sometimes someone else might be accused of stealing which may occur more frequently over time. For example, your dad may insist that a friend keeps stealing his money, whereas its in its regular hiding place.
Other examples that may indicate potential dementia symptoms could include:
- Teabags in the fridge and leaving the milk out
- Toothbrush in the washing basket
- Remote control in the cutlery drawer
- Dirty laundry in the dishwasher
Misplacing or losing items is more common in Alzheimers Disease, rather than vascular dementia. Find out more about the different types of dementia.
What Causes Alzheimer Disease
Lots of research is being done to find out more about the causes of Alzheimer disease. There is no one reason why people get it. Older people are more likely to get it, and the risk increases the older the person gets. In other words, an 85-year-old is more likely to get it than a 65-year-old. And women are more likely to get it than men.
Researchers also think genes handed down from family members can make a person more likely to get Alzheimer disease. But that doesn’t mean everyone related to someone who has it will get the disease. Other things may make it more likely that someone will get the disease, such as high blood pressure, high cholesterol, Down syndrome, or having a head injury.
On the positive side, researchers believe exercise, a healthy diet, and taking steps to keep your mind active may help delay the start of Alzheimer disease.
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Difficulty Completing Familiar Tasks
Some people may experience a greater problem with concentration. Routine day-to-day tasks requiring critical thought may take longer as the disease progresses.
The ability to drive safely may also be called into question. If you or a loved one gets lost while driving a commonly traveled route, this may be a symptom of AD.
Where To Get Help
- Your local community health centre
- National Dementia Helpline Dementia Australia Tel. 1800 100 500
- Aged Care Assessment Services Tel. 1300 135 090
- My Aged Care 1800 200 422
- Cognitive Dementia and Memory Service clinics Tel. 1300 135 090
- Carers Victoria Tel. 1800 242 636
- Commonwealth Carelink and Respite Centres Australian Government Tel. 1800 052 222
- Dementia Behaviour Management Advisory Service Tel. 1800 699 799 for 24-hour telephone advice for carers and care workers
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What Are The Signs Of Alzheimer’s Disease
Scientists continue to unravel the complex brain changes involved in the onset and progression of Alzheimers disease. It seems likely that damage to the brain starts a decade or more before memory and other cognitive problems appear. During this preclinical stage of Alzheimers disease, people seem to be symptom-free, but toxic changes are taking place in the brain.
Damage occurring in the brain of someone with Alzheimers disease begins to show itself in very early clinical signs and symptoms. For most people with Alzheimersthose who have the late-onset varietysymptoms first appear in their mid-60s. Signs of early-onset Alzheimers begin between a persons 30s and mid-60s.
The first symptoms of Alzheimers vary from person to person. Memory problems are typically one of the first signs of cognitive impairment related to Alzheimers disease. Decline in non-memory aspects of cognition, such as word-finding, vision/spatial issues, and impaired reasoning or judgment, may also signal the very early stages of Alzheimers disease. And some people may be diagnosed with mild cognitive impairment. As the disease progresses, people experience greater memory loss and other cognitive difficulties.
Alzheimers disease progresses in several stages: preclinical, mild , moderate, and severe .
What Causes Alzheimer’s Disease
Alzheimer’s disease happens because of changes in the brain. Some of the symptoms may be related to a loss of chemical messengers in the brain, called neurotransmitters, that allow nerve cells in the brain to communicate properly.
People with Alzheimer’s disease have two things in the brain that are not normal: amyloid plaques and neurofibrillary tangles. Experts don’t know if amyloid plaques and neurofibrillary tangles are side effects of Alzheimer’s disease or part of the cause.
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What Is Alzheimer Disease
Alzheimer disease, which affects some older people, is different from everyday forgetting. It is a condition that permanently affects the brain. Over time, the disease makes it harder to remember even basic stuff, like how to tie a shoe.
Eventually, the person may have trouble remembering the names and faces of family members or even who he or she is. This can be very sad for the person and his or her family.
It’s important to know that Alzheimer disease does not affect kids. It usually affects people over 65 years of age. Researchers have found medicines that seem to slow the disease down. And there’s hope that someday there will be a cure.
What Other Factors Have Contributed To Eco
The apocalyptic nature of climate-change-induced-devastation has been a cause of concern among people, especially the youth. However, what has also contributed to eco-anxiety among many other things is the rank indifference of those in influential and powerful positions.
A 10-country survey, involving 10,000 respondents between the ages of 16 and 25, was conducted by Englands Bath University in collaboration with five universities, with funding from US non-profit organisation Avaaz. Released in September 2021, it revealed that the startling condition of eco-anxiety among the young population was as much a result of governmental inaction on climate change as it was from the degradation of nature.
An overwhelming majority of around 75-83 percent painted a grim picture of the future to varying degrees with some even considering not having children. When asked if the governments have failed young people and if they can be trusted, 65 percent agreed with the former question and only 31 percent with the latter.
The studys lead author Caroline Hickman told BBC News, The young feel abandoned and betrayed by governments. Were not just measuring how they feel, but what they think. Four out of 10 are hesitant to have children.
On 28 September, 2021, a few days after the results of the survey was published, iconic climate change activist Greta Thunberg vehemently criticised those not taking concrete steps to reverse the damage done to the environment.
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Other Conditions With Similar Symptoms
Early in the disease, Alzheimer’s usually doesn’t affect a person’s fine motor skills or sense of touch. So a person who develops motor symptoms or sensory symptoms probably has a condition other than Alzheimer’s disease. Conditions such as Parkinson’s disease, for instance, may cause motor symptoms along with dementia.
Other conditions with symptoms similar to those of Alzheimer’s disease may include:
- Dementia caused by small strokes .
- Thyroid problems, such as hyperthyroidism or hypothyroidism.
- Other problems such as kidney and liver disease and some infections such as HIV .
Frequently Misplacing Items And Not Being Able To Retrace Steps
Most people will lose items at some time, but they are usually able to locate them again by searching in logical locations and retracing their steps.
However, someone with Alzheimers disease may forget where they placed an item, especially if they put it in an unusual place. They may also be unable to retrace their steps to find the missing item. This can be distressing and may cause the person to believe that someone is stealing from them.
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What Are The Signs And Symptoms Of Alzheimers
Memory problems are often one of the first signs of Alzheimers. Symptoms vary from person to person, and may include problems with:
- Word-finding, or having more trouble coming up with words than other people the same age.
- Vision and spatial issues, like awareness of the space around them.
- Impaired reasoning or judgment, which can impact decisions.
Other symptoms may be changes in the persons behavior, including:
- Taking longer to complete normal daily tasks.
- Repeating questions.
- Trouble handling money and paying bills.
- Wandering and getting lost.
- Losing things or misplacing them in odd places.
- Mood and personality changes.
- Increased anxiety and/or aggression.
How To Spot Early Indicators That Your Loved One May Have Alzheimers Or Dementia
by Patrick J. Kiger, AARP, Updated May 4, 2021| 0
En español | From age 50 on, its not unusual to have occasional trouble finding the right word or remembering where you put things.
But persistent difficulty with memory, cognition and ability to perform everyday tasks might be signs that something more serious is happening to a loved ones brain.
Dementia isnt actually a disease, according to the Mayo Clinic. Its a catch-all term for changes in the brain that cause a loss of functioning that interferes with daily life. Dementia can diminish focus, the ability to pay attention, language skills, problem-solving and visual perception. It also can make it difficult for a person to control his or her emotions and lead to personality changes.
More than 6 million Americans are living with Alzheimer’s dementia, according to a 2021 report by the Alzheimer’s Association. Alzheimer’s disease is the leading cause of dementia, accounting for 60 percent to 70 percent of cases, but a range of brain illnesses can lead to the condition .
Diseases that cause dementia
These conditions are the leading causes of dementia. Many patients have mixed dementia, a combination of two or more types, such as Alzheimers and vascular dementia.
Vascular dementia. The second most common type of dementia is caused from damage to the vessels that supply blood to the brain. It tends to affect focus, organization, problem-solving and speed of thinking more noticeably than memory.
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What Is The Difference Between Alzheimer’s And Dementia
First, some explanation of dementia vs. Alzheimer’s. According to the Alzheimer’s Association, dementia is a general term for a decline in mental ability that interferes with daily life. Not a normal part of aging, most dementias are typically caused by damaged brain cells.
Of all the dementias, Alzheimer’s disease is the most common, accounting for 60-80% of the cases. In other words, it is a specific disease while “dementia” is a general term for a life-altering decline in brain function .
When To See A Doctor
Forgetfulness and memory problems dont automatically point to dementia. These are normal parts of aging and can also occur due to other factors, such as fatigue. Still, you shouldnt ignore the symptoms. If you or someone you know is experiencing a number of dementia symptoms that arent improving, talk with a doctor.
They can refer you to a neurologist who can examine you or your loved ones physical and mental health and determine whether the symptoms result from dementia or another cognitive problem. The doctor may order:
- a complete series of memory and mental tests
- a neurological exam
- brain imaging tests
If youre concerned about your forgetfulness and dont already have a neurologist, you can view doctors in your area through the Healthline FindCare tool.
Dementia is more common in people over the age of 65, but it can also affect younger people. Early onset of the disease can begin when people are in their 30s, 40s, or 50s. With treatment and early diagnosis, you can slow the progression of the disease and maintain mental function. The treatments may include medications, cognitive training, and therapy.
Possible causes of dementia include:
- Alzheimers disease, which is the leading cause of dementia
- brain damage due to injury or stroke
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What Are The Stages Of Alzheimers
Alzheimers disease slowly gets worse over time. People with this disease progress at different rates and in several stages. Symptoms may get worse and then improve, but until an effective treatment for the disease itself is found, the persons ability will continue to decline over the course of the disease.
Early-stage Alzheimers is when a person begins to experience memory loss and other cognitive difficulties, though the symptoms appear gradual to the person and their family. Alzheimers disease is often diagnosed at this stage.
During middle-stage Alzheimers, damage occurs in areas of the brain that control language, reasoning, sensory processing, and conscious thought. People at this stage may have more confusion and trouble recognizing family and friends.
In late-stage Alzheimers, a person cannot communicate, is completely dependent on others for care, and may be in bed most or all the time as the body shuts down.
How long a person can live with Alzheimers disease varies. A person may live as few as three or four years if he or she is older than 80 when diagnosed, to as long as 10 or more years if the person is younger. Older adults with Alzheimers disease need to know their end-of-life care options and express their wishes to caregivers as early as possible after a diagnosis, before their thinking and speaking abilities fail.
How To Know If You Have Alzheimer’s
12 August 2009
This Week’s Question:I’ve been forgetting names of people lately and I have this dread that this is an early symptom of Alzheimer’s. How can I tell?
I don’t know a geezer who hasn’t asked this question. Once you hit 60, you begin to wonder if your lost keys have greater significance than they did when you were younger.
The scary truth is that Alzheimer’s begins with difficulty remembering the familiar people, things, events. Or, you start having trouble doing simple arithmetic in your head. These annoyances are common to seniors with healthy brains, so most of us don’t get too worked up over them.
But, as Alzheimer’s progresses, it can make people forget how to brush their teeth or change channels on a TV. And it gets worse until patients require complete care.
So, when should you go to your doctor to discuss your memory lapses?
That’s a personal judgment call. I’ve found that I can’t remember the names of movie stars and ballplayers the way I used to. I attribute this to what I call the “overloaded filing cabinet.” As we get older, we accumulate so many memories that it’s impossible to find the one we want.
I’m not sufficiently worried about my memory difficulties to mention them to my doctor. But if you are worried, get tested.
And then there are those pesky emotions. Feeling sad, lonely, worried, or bored can affect people facing retirement or coping with the death of a loved one. Adapting to change can make you forgetful.
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How Is Alzheimer’s Disease Diagnosed
Doctors use several methods and tools to help determine whether a person who is having memory problems has possible Alzheimers dementia , probable Alzheimers dementia , or some other problem.
To diagnose Alzheimers, doctors may:
- Ask the person and a family member or friend questions about overall health, use of prescription and over-the-counter medicines, diet, past medical problems, ability to carry out daily activities, and changes in behavior and personality
- Conduct tests of memory, problem solving, attention, counting, and language
- Carry out standard medical tests, such as blood and urine tests, to identify other possible causes of the problem
- Perform brain scans, such as computed tomography , magnetic resonance imaging , or positron emission tomography , to rule out other possible causes for symptoms
These tests may be repeated to give doctors information about how the persons memory and other cognitive functions are changing over time. They can also help diagnose other causes of memory problems, such as stroke, tumor, Parkinsons disease, sleep disturbances, side effects of medication, an infection, mild cognitive impairment, or a non-Alzheimers dementia, including vascular dementia. Some of these conditions may be treatable and possibly reversible.
People with memory problems should return to the doctor every 6 to 12 months.
Where To Find Help
When your loved one is displaying troubling symptoms, a trip to a primary care physician is often the first step. But to get a definitive diagnosis, youll need to see a specialist such as a neurologist, geriatrician or geriatric psychiatrist.
If you cant find one, the National Institute on Aging recommends contacting the neurology department of a nearby medical school. Some hospitals also have clinics that focus on dementia.
Ailments can mimic dementia
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